CDC25 Phosphatase Inhibitor I

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BN82002 is a synthetic inhibitor of CDC25 phophatases.

BN-82002, also known as CDC25 Phosphatase Inhibitor I, is a cell-permeable ortho-hydroxybenzylamino compound that displays anti-tumor properties. BN-82002 acts as a potent, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 μM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro. It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation. In synchronized HeLa cells, BN82002 delays cell cycle progression at G1-S, in S phase and at the G2-M transition.

BN-82002;CDC25 Phosphatase Inhibitor I; PTP Inhibitor XX;

Metabolic Enzyme/Protease

Phosphatase

CDC25A;CDC25B2;CDC25B3;CDC25C;CDC25C-cat

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396073-89-5

359.42

C19H25N3O4

98%

DMSO : ≥ 150 mg/mL; 417.34 mM

Oc1c(cc(cc1OC)N(C)C)CN(C)CCc2ccc(cc2)[N+]([O-])=O

Phenol, 4-(dimethylamino)-2-methoxy-6-((methyl(2-(4-nitrophenyl)ethyl)amino)methyl)-

(-20℃)

With Ice Pack

≥ 2 years